• Aging/Living
  • Aging Events
    • Mitochondrion Dysfunction
    • Lack of ATP
    • Reactive Oxygen Species
    • Lipid Peroxidation
    • Glycation
    • Protein cross-links
    • Amyloidosis
    • Advanced Glycation End Products
    • DNA Strand Breaks
    • DNA Cross-links
    • Cellular Senescence
    • Apoptosis
    • Epigenetic Changes
    • Irreversible Cell Growth Arrest
    • DNA Methylation
    • MicroRNA Expression
    • Dysmorphic Nuclear Envelope
    • Lamin A Missplicing
    • Gene Expression Alteration
    • Alterations of Expression Patterns of CLOCK and BMAL1
    • Imbalances in lipid metabolism
    • Steroids hormone Imbalance
    • Endocrinosenescence
    • Insulin resistance
    • Lysosomal dysfunction
    • Senescence associated secretory phenotype
    • Chronic Inflammation
    • Stem cell aging and aberrant differentiation within the niche
    • Regenerative capacity decreasin
    • Immunosenescence
    • Thymus atrophy
  • Aging Biomarkers (Increasing)
    • Mitochondrial dna deletions
    • COX-2
    • Glycosylated hemoglobin
    • Malonic dialdehyde
    • Pentosidine
    • RAGEs
    • y-H2AX foci
    • 8-oxoG
    • Chromosomal translocations
    • Lipfuscin
    • H4K16 acetylation
    • The methylation of promoters of the EDARADD, TOM1l!, and NPXT2 genes
    • DAPI-defined senescence associated heterochromatin foci
    • NOX4
    • miR-34a, miR-217
    • miR-29
    • ARF p16, p21, p53
    • CRAMP stathmin EF-1 chitinase
    • Caveolin-1
    • Progerin
    • JMJD3
    • Leptin
    • Total Cholesterol LDL-cholesterol Triglycerides Free Fatty Acides VLDL Cholesterol
    • Adiponectin
    • Glucocorticoids (cortisol)
    • Senescence-associated B-galactosidase
    • Extracellular matrix metalloproteinases
    • TNFa, MCP-1, Interluekin-6, Interluekin-8, C3, C4
    • NF-kB activity
    • C-reactive protein
  • Aging Biomarkers (Decreasing)
    • Lon
    • Proteasome Autophagy
    • Telomere Length
    • Activity of SIRT-1
    • Methylation of repeat sequences
    • Trimethylation of H3K27
    • miRa-18, miR-19a, miR-19b in cardiomyocytes
    • miR-146a in endotheliocytes
    • Peripheral Heterochromatin
    • Telomerase, c-myc
    • HDL Cholesterol
    • Melatonin
    • DHEA
    • 1,25(OH)2D3
    • Growth hormone IGF-1
    • Wound Healing
    • IFN-y, Interluekin-2, Interluekin-7, Interluekin-10
    • Resistance to viral infection
    • B cell antibody
    • Naive T cell number
  • Aging-Dependant Pathologies
    • Cataract
    • Senile systemic amyloidosis
    • Alzheimer's disease
    • Cancer
    • Brown atrophy of the heart
    • Myocardial infarction
    • Retinal degeneration
    • Stroke
    • Atherosclerosis
    • Thrombosis
    • Vascular Dementia
    • Arterial hypertension
    • Chronic kidney failure
    • Arterial Anuerysm
    • Heart failure
    • Coronary heart disease
    • Circadian dysfunction
    • Obesity
    • Osteoporosis
    • Hyperadaptosis
    • Type 2 diabetes mellitus
    • Rhuematoid arthritis
    • Autoimmunity
    • Sarcopenia
    • Immunodeficiency
  • Pathology Markers
    • Serum amyloid A
    • Beta-amyloid in cerebrospinal fluid
    • Ankle-arm index, Aortic pulse wave velocity
    • Soluble fibrin Prothrombin fragment 1.2 Plasmin/a2-antiplasmin complex
    • Clinical Dementia Rating, Mini-mental state examination
    • CTGF, TSP1
    • Serum resistin
    • Bone mineral density, Serum osteocalcin, Bone ALP
    • uNTx, sNTx
    • Glucose in the blood and urine
    • Rhuematoid Factor